Nervous System
Principle The sciatic nerve of mice is partially ligated to simulate low back pain observed in human.
Sample requirements Male C57 mice of 8 weeks old
Testing instrument Dynamic Plantar Aesthesiometer (Von Frey, Ugo Basile)
Service cycle 14 business days
Figure 1 Modeling method
Principle The drug MPTP can disrupt the dopamine pathway between the mouse striatum and the substantia nigra to mimic human Parkinson's disease.
Sample requirements Male C57 mice of 10 weeks old
Testing instruments and consumables Rotating-beam fatigue-testing machine, climbing poles, MPTP (SIGMA)
Service cycle 14 business days
图1 MPTP Latency on Rotarod (sec)
