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Mice

hGIPR

Strain Name：C57BL/6Smoc-Giprtm1(hGIPR)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-225064

The endogenous mouse Gipr gene was replaced by human GIPR gene.

Mice

hCD40/hPD-1/hPD-L1

Strain Name：C57BL/6Smoc-Cd40em1(hCD40)Pdcd1em1(hPDCD1)Cd274em1(hPD-L1)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210406

hPD-1/hPD-L1(NM-HU-00100) was crossed with hCD40（NM-HU-00076）to generate hCD40/hPD-1/hPD-L1 mice

Mice

Isl1-CreERT2

Strain Name：C57BL/6Smoc-Isl1em1(CreERT2) Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00013

CreERT2 was inserted at the start codon (ATG site). The KI mice have a tamoxifen-inducible cre-mediated recombination system.

Mice

Lyz2-2A-CreERT2

Strain Name：C57BL/6Smoc-Lyz2em1(2A-CreERT2-WPRE-pA)Smoc
Strain State：Repository Live | Cat. NO.：NM-KI-18018

A 2A-CreERT2-WPRE-pA coexpression cassette is inserted befor the stop codon of mouse Lyz2 gene via homologous recombination to establish a tamoxifen inducible Lyz2-CreERT2 tool stain. This strain can be used to knockout target gene in Lyz2+ cells after tamoxifen treatment when crossed with mice which carry loxp sites flanking target gene.

Mice

hPVRL2

Strain Name：C57BL/6Smoc-Nectin2tm1(hNECTIN2)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000084

The endogenous mouse Nectin2 gene was replaced by human PVRL2 gene.

Mice

hTIGIT(3)

Strain Name：C57BL/6Smoc-Tigittm3(hTIGIT)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-200244

The endogenous mouse Tigit gene was replaced by human TIGIT gene. While hTIGIT(Stock No.NM-HU-00053) mice function similarly to hTIGIT（3） mice ,for more detailed information please contact our technical advisor.

Mice

Axin2-CreERT2

Strain Name：C57BL/6Smoc-Axin2em1(CreERT2-pA)Smoc
Strain State：Developing | Cat. NO.：NM-KI-200109

A CreERT2-pA expression cassette was knocked into the Axin2 gene start codon site. As Axin2 is an intracellular protein, it is essential for identifying a surface marker for stem cell purification. When these Axin2-CreERT2 mice are bred with mice containing a loxP-flanked sequence of interest, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the flanked sequences in Axin2 expressing cells.

Mice

hTP53(2)

Strain Name：C57BL/6Smoc-Trp53tm1(hTP53)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-225052

The endogenous mouse Trp53 gene was replaced by human TP53 gene.

Mice

hCSF1/hCSF1R(BALB/c)

Strain Name：BALB/cAnSmoc-Csf1tm2(CSF1)Csf1rem3(hCSF1R)/Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-220016

The endogenous mouse Csf1 and Csf1r genes was replaced respectively by human CSF1 and CSF1R genes.

Mice

Col1a1-TRE3G-dCas9-VPR-EGFP

Strain Name：C57BL/6Smoc-Col1a1em1(TRE3G-dCas9-VPR-eGFP-pA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-KI-00123

These mice harbor a TRE3G-dCas9-VPR(VP64-p65-Rta)-eGFP-pA tetracycline-controlled transcriptional activation cassette in mouse Col1a1 loci. This strain can be used in CRISPR mediated target gene transcriptional activation (CRISPRa).

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