Gad2-IRES-Cre

Nomenclature

C57BL/6Smoc-Gad2em1(IRES-iCre-pA)Smoc

Cat. NO.

NM-KI-200078

Strain State

Repository Live

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Model Description

A IRES-iCre-pA expression cassette was knocked into the Gad2 gene stop codon site.
Research Application：By mating the reporter mice with Cre-expressing mice, Gad2 positive cells derived from double-positive mice were permanently labeled by fluorescent protein. It can be used to trace Gad2-positive cells.

Validation Data

Gad2-iCre-1.png

Fig. 1 Detection of tdTomato (red) in the retina of Gad2icre/+; Rosa26tdTomato/+ mice. Cre-mediated recombination in the retinal ganglion cell layer (yellow arrow) and inner nuclear layer (red arrow) of Gad2iCre/+; Rosa26tdTomato/+ mouse. 

Gad2-iCre-2.png

Fig. 2 Detection of tdTomato (red) in some cells of the cortex and hippocampus drived from Gad2icre/+; Rosa26tdTomato/+ mice.

Gad2-iCre-3.png

Fig. 3 Detection of tdTomato (red) in various tissues of Gad2icre/+; Rosa26tdTomato/+ mice. Cre-mediated recombination in some cells of the brain, pituitary gland, retina, lung, heart, liver, submandibular gland, brown fat, kidney, pancreas, intestine, colon,  epididymis, muscle, skin and thymus can be observed. Tdtomato can not be detected in the spleen and testis. (For more detailed information please contact our technical advisor.)

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