hCD7(2)

Nomenclature

C57BL/6Smoc-Cd7em2(hCD7)Smoc

Cat. NO.

NM-HU-232423

Strain State

Repository Live

Export PDF

Model Description

The endogenous mouse Cd7 gene was replaced by human CD7 gene.

Validation Data

image.png

Fig.1 Detection of CD7 expression in duodenum and small intestine by RT-PCR. 

Wild type: only one band at 107 bp with primers F1/R1 (mCd7);

Homozygous: only one band at 163 bp with primers F2/R2 (hCD7).

Abbr. M, DNA marker; HO, homozygous; WT, wild type.

image.png

Fig.2 Detection of m/h CD7 expression on T cells in Blood (A), spleen (B) and thymus (C) in hCD7(2) KI mice.

image.png

Fig.3 Detection of hCD7 expression on T cells in Blood (A), spleen (B) and thymus (C) in hCD7(2) KI mice.

image.png

Fig.4 Detection of m/h CD7 expression on NKs in Blood (A) and spleen (B) in hCD7(2) KI mice.

image.png

Fig.5 Analysis of leukocytes cell subpopulation in Spleen (A) and thymus (B) in WT and HO hCD7(2) mice.


You may also like

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

Learn more
Customizing Mouse Models: Delivering in 100 Days to Speed Up Your Research!

At GenoBioTX, we understand that the lengthy wait times for gene-modified mouse models can hinder your research progress. Traditional methods often require 6-9 months, leading to delays and increased costs. That’s why we’re thrilled to introduce our innovative service designed to streamline this process and deliver results faster.

Learn more