H11-pAlb-hBAFF

Nomenclature

C57BL/6Smoc-Igs2em1(pAlb-hBAFF-pA)Smoc

Cat. NO.

NM-KI-232137

Strain State

Sperm cryopreservation

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Gene Summary

Gene Symbol

Model Description

The pAlb-hBAFF-pA expression cassette was knocked into the H11 locus.

Validation Data

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Fig.1 Detection of hBAFF expression in serum by ELISA. 

Abbr.  WT, wild type; HE, heterozygous.

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Fig.2 Detection of immune phenotype in WT C57BL/6 and HE H11-pAlb-hBAFF mice.

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Fig.3 Detection of phenotype in Peripheral blood in WT C57BL/6 and HE H11-pAlb-hBAFF mice.

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Fig.4 Detection of phenotype in Spleen in WT C57BL/6 and HE H11-pAlb-hBAFF mice.

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Fig.5 Detection of phenotype in Lymph node in WT C57BL/6 and HE H11-pAlb-hBAFF mice.

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Fig.6 Detection of phenotype in Bone marrow in WT C57BL/6 and HE H11-pAlb-hBAFF mice.

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Fig.7 Body weight(A) and urine biochemistry analysis(B) of H11-pAlb-hBAFF mice at different time points. (Day 0 : 9 Weeks age)

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Fig.8 Tissue weights and photos of H11-pAlb-hBAFF mice at different time points.

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Fig.9 Detect the dsDNA levels in the blood of H11-pAlb-hBAFF mice at 11 weeks of age. (Kit information: Apha Diagnostic, 5120)

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Fig.10 Expression characterization of mIgA (A), mIgE (B), mIgM (C) and mIgG (D) in HE H11-pAlb-hBAFF mice by ELISA.



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