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SNX10-mediated LPS sensing causes intestinal barrier dysfunction via a caspase-5-dependent signaling cascade

Model Organisms：Mice Product & Service：Snx10-floxed Research field：IBD

Published date：2021-09-30 | References：EMBO J

Gut Microbial Metabolite Pravastatin Attenuates Intestinal Ischemia/Reperfusion Injury Through Promoting IL-13 Release From Type II Innate Lymphoid Cells via IL-33/ST2 Signaling

Model Organisms：Mice Product & Service：Rag1-KO;Il33-KO(2) Research field：Gut Microbial Metabolite Pravastatin

Published date：2021-09-28 | References：Frontiers in Immunology

METTL14 aggravates podocyte injury and glomerulopathy progression through N6-methyladenosine-dependent downregulating of Sirt1

Model Organisms：Mice Product & Service：Mettl14-Flox Research field：podocyte injury and glomerulopathy

Published date：2021-09-27 | References：Cell Death and Disease

https://www.thno.org/v11p9623.htm

Model Organisms：Mice Product & Service：Rosa26-LSL-linc-AhRA Research field：autoimmune

Published date：2021-09-21 | References：THERANOSTICS

RACK1 T50 Phosphorylation by AMPK Potentiates Its Binding with IRF3/7 and Inhibition of Type 1 IFN Production

Model Organisms：Mice Product & Service：Rack1-Flox Research field：Inflammation

Published date：2021-09-01 | References：Journal of Immunology

E3 ligase MKRN3 is a tumor suppressor regulating PABPC1 ubiquitination in non-small cell lung cancer

Model Organisms：Mice Product & Service：Mkrn3-Flox Research field：Cancer Research

Published date：2021-08-02 | References：J Exp Med

MicroRNA-96 is required to prevent allodynia by repressing voltage-gated sodium channels in spinal cord

Model Organisms：Mice Product & Service：mir 96 cko;gad2-creERT2 Research field： research of pain relief ; central nervous system disorders

Published date：2021-07-23 | References：ELSEVIER

hACE2 Fc-neutralization antibody cocktail provides synergistic protection against SARS-CoV-2 and its spike RBD variants

Model Organisms：Mice Product & Service：hACE2 Research field：COVID-19

Published date：2021-07-20 | References：cell discovery

Targeting sorting nexin 10 improves mouse colitis via inhibiting PIKfyve-mediated TBK1/c-Rel signaling activation

Model Organisms：Mice Product & Service：Snx10-flox Research field：Inflammation

Published date：2021-07-15 | References：Pharmacological Research

Blocking FcγRIIB in Smooth Muscle Cells Reduces Hypertension

Model Organisms：Mice Product & Service：Fcgr2b-Flox Research field：Cardiovascular Research

Published date：2021-07-09 | References：Circulation Research

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