Col4a5-R471X
Nomenclature
C57BL/6Smoc-Col4a5em1(R471X)Smoc
Cat. NO.
NM-KI-200183
Strain State
Repository Live
Gene Summary
Gene Symbol
Col4a5
Model Description
These mice carry a R471X mutation of Col4a5 gene.
Disease Connection
Validation Data
Fig1. Col4a5 mRNA level was measured in Col4a5-R471X mice (n=3, male, 6 week-old) and the point mutation of Col4a5 has been verified by sequencing.
Abbr. HO, homozygous; WT, wild type.
Fig2. The results of urine (A) and blood (B) biochemical indicators in Col4a5-R471X mice (n=2 male and 6 female).
Abbr. WT, wild type.
Fig3. The results of urine (A) and plasma (B) biochemical indicators in 21-weeks-old Col4a5-R471X mice (n=3/group).(Data from a cooperator)
Abbr. WT, wild type.
Fig 4. Effects of Ramipril (10mg/kg) on urine (A) and blood (B) biochemical indicators of Col4a5-R471X mice over a 16-17 weeks treatment period (6 weeks of age at initiation time, n=4-5 male and 4-5 female in each group).
Abbr. WT, wild type.
Fig 5. Effects of Ramipril (10mg/kg) on urine (A) and plasma (B) biochemical indicators of male and female Col4a5-R471X mice over a 16-17 weeks treatment period respectively (6 weeks of age at initiation time, n=4-5 male and 4-5 female in each group).
Abbr. WT, wild type.
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