Gla-KO

Nomenclature

C57BL/6Smoc-Glaem1Smoc

Cat. NO.

NM-KO-200601

Strain State

Repository Live

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Gene Summary

Gene Symbol
Gla

Synonyms

Ags

NCBI ID

11605

MGI ID

1347344

Ensembl ID

ENSMUSG00000031266

Pubmed

Gla

Human Ortholog

GLA

Model Description

Exon 2-3 of Gla gene was deleted to generate Gla knockout mice.
Research Application：Fabry Disease research

Disease Connection

Fabry Disease

Phenotype(s)

MGI:2183938

Reference(s)

Ohshima T, Murray GJ, Swaim WD, Longenecker G, Quirk JM, Cardarelli CO, Sugimoto Y, Pastan I, Gottesman MM, Brady RO, Kulkarni AB, alpha-Galactosidase A deficient mice: a model of Fabry disease. Proc Natl Acad Sci U S A. 1997 Mar 18;94(6):2540-4

Validation Data

image.png

Fig1. Detection of Gla expression in brain by RT-PCR (A) and qPCR (B). 

Wild type: only one band at 268 bp with primers F1/R1(mGla).

Abbr. M, DNA marker; WT, wild type.

image.png

Fig2. Detection of serum GLA activity (A) and serum lyso-Gb3 levels (B) in 14 weeks old male Gla-KO mice. (Data from the collaborator)

image.png

Fig3. Hot plate test of 14 weeks old male Gla-KO mice. (Data from the collaborator)

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