hF12

Nomenclature

C57BL/6Smoc-F12tm1(hF12)/Smoc

Cat. NO.

NM-HU-210017

Strain State

Repository Live

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Gene Summary

Gene Symbol
F12

Synonyms

HAF; FXII

NCBI ID

58992

MGI ID

1891012

Ensembl ID

ENSMUSG00000021492

Pubmed

F12

Human Ortholog

F12

Model Description

The endogenous mice F12 gene was replaced by human F12 gene.
Research Application：drug screening

Validation Data

image.png

Fig1. Detection of F12 expression in liver by RT-PCR. 

Wild type: only one band at 318 bp with primers F1/R1(mF12);

Homozygous: only one band at 274 bp with primers F2/R2(hF12); 

Abbr. M, DNA marker; HO, homozygous; HE, heterozygous; WT, wild type.

image.png

Fig.2 Detection of human F12 (A) and mouse F12 (B) expression in serum by ELISA (male, 8-11wks, n=2). 

Abbr. HO, homozygous; WT, wild type.

image.png

Fig.3 Detection of hF12 expression in serum by ELISA (male, n=3). 

Abbr. HO, homozygous; WT, wild type.  

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