hMRGPRX2

Nomenclature

C57BL/6Smoc-Mrgprb2em1(hMRGPRX2)Smoc

Cat. NO.

NM-HU-234361

Strain State

Repository Live

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Gene Summary

Gene Symbol
Mrgprb2

Model Description

The endogenous mouse Mrgprb2 gene was replaced by human MRGPRX2 gene.

Validation Data

image.png

Fig.1 Detection of MRGPRX2 expression in bladder by RT-PCR. 

Wild type: only one band at 265 bp with primers F1/R1 (mMrgprb2);

Homozygous: only one band at 383 bp with primers F2/R2 (hMRGPRX2).

Abbr. M, DNA marker; HO, homozygous; WT, wild type.

image.png

Fig.2 Characterization of MRGPRX2 (X2) Expression. huX2 immunoreactivity was observed in flow isolated peritoneal mast cells (PMCs) from X2-KI but not WT control mice or staining controls (isotype CTR). (Data from a collaborator)

image.png

Fig.3 MRGPRX2 is not expressed on macrophages (as expected).  (Data from a collaborator)


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