hTHPO(NMG)
Nomenclature
NOD-PrkdcscidIl2rgem1Thpotm(hTHPO)Smoc
Cat. NO.
NM-HU-220429
Strain State
Repository Live
Gene Summary
Gene Symbol
Thpo
Model Description
The hTHPO(NM-HU-2000062) mice were backcrossed to NMG genetic background, to create the new strain of hTHPO(NMG) (NM-HU-220429) mice.
Validation Data
Fig.1 Detection of THPO expression in adrenal and liver by RT-PCR.
Wild type: only one band at 166 bp with primers F1/R1(mThpo);
Homozygous: only one band at 167 bp with primers F2/R2(hTHPO).
Abbr. M, DNA marker; HO, homozygous; WT, wild type.
Fig.2 Detection of hTHPO expression in serum and liver homogenate by ELISA (male, 6-11wks).
Abbr. HO, Homozygous; WT, wild type.
Note. hTHPO(NMG) and NMG mice were i.p. injected with LPS. The Human Thrombopoietin ELISA Kit cross-reacted with mouse THPO and humanized THPO.
Fig.3 Detection of hTHPO expression in hTHPO(NMG) mice by WB.
Abbr. M, marker; WT, wild type; PC, positive control, Hela cells.
Note. The anti-human THPO Antibody cross-reacted with mouse THPO and humanized THPO.
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