Il1b-Luc-Tg

Nomenclature

B6.Cg-Tg(IL1B-luc)Smoc

Cat. NO.

NM-TG-00001

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol

Synonyms

Il-1b， IL-1beta

NCBI ID

16176

MGI ID

96543

Ensembl ID

ENSMUSG00000027398

Pubmed

Human Ortholog

IL1B

Model Description

The transgenic mice model could be used to study transcriptional regulation of the IL-1βgene expression in the inflammatory process and evaluation the effect of anti-inflammatory drug in vivo.
Research Application：anti-inflammatory,inflammatory process

Validation Data

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Fig.1 Time course of mean fluorescence intensity on the ventral and dorsal of Il1b-Luc-Tg mice after 5mg/mL LPS administration.

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Fig.2 Individual fluorescence intensity on the ventral (A) and dorsal (B) of Il1b-Luc-Tg mice treated with LPS.

Publications

Functional imaging of interleukin 1 beta expression in inflammatory process using bioluminescence imaging in transgenic mice
References：BMC Immunol

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