hIL17A/hIL17F
Nomenclature
C57BL/6Smoc-Il17atm1(hIL17A)Il17fem2(hIL17F)Smoc
Cat. NO.
NM-HU-200281
Strain State
Repository Live
Gene Summary
Gene Symbol
IL17A
Gene Symbol
IL17F
Model Description
Validation Data
Fig1. Analysis of IL17F gene expression in the kidney by RT-PCR. Mouse Il17f mRNA was detectable by P1/2(440bp), human IL17F mRNA was detectable by P3/4(259bp), M:100bp Plus DNA ladder from Transgen (BM311). The heterozygous KI mice express both human IL17F and mouse Il17f in the kidney.
Fig2. Analysis of IL17A gene expression in the spleen by RT-PCR in WT and IL17A/IL17F humanized mice . Mouse Il17a mRNA was detectable by P1/2(490bp), human IL17A mRNA was detectable by P3/4(443bp), M:100bp Plus DNA ladder from Transgen (BM311). The heterozygous KI mouse expresses both human IL17A and mouse Il17a in the spleen.
Fig. 3 Detection of hIL17A expression in serum, spleen and thymus homogenate by ELISA (n=3).
Abbr. HO, homozygous; WT, wild type.
Note. hIL17A/hIL17F and C57BL/6 mice were i.p. injected with LPS.
Fig. 4 Detection of hIL17F expression in serum, spleen and thymus homogenate by ELISA (n=3).
Abbr. HO, homozygous; WT, wild type.
Note. hIL17A/hIL17F and C57BL/6 mice were i.p. injected with LPS.
You may also like
On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
Learn moreAt GenoBioTX, we understand that the lengthy wait times for gene-modified mouse models can hinder your research progress. Traditional methods often require 6-9 months, leading to delays and increased costs. That’s why we’re thrilled to introduce our innovative service designed to streamline this process and deliver results faster.
Learn more
