hSTING

Nomenclature

C57BL/6Smoc-Tmem173tm2(hTMEM173)Smoc

Cat. NO.

NM-HU-190036

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol
Tmem173

Model Description

The endogenous mouse Tmem173 gene was replaced by human TMEM173 gene.
Research Application:Immunotherapy,cancer research,drug screening

Validation Data

sting-cd4.png

Fig1 The expression of human STING in CD4+ T lymphocytes of humanized STING mice was measured by FACS. In heterozygous humanized STING mice, active expression of human STING was detected in CD4+ T lymphocytes derived from blood, spleen, thymus and lymph node. 

sting-cd8.png

Fig2 The expression of human STING in CD8+ T lymphocytes of humanized STING mice was measured by FACS. In heterozygous humanized STING mice, active expression of human STING was detected in CD8+ T lymphocytes derived from blood, spleen, thymus and lymph node. 

sting-3.png

Fig3 The expression of human STING in the heart and lung cells was measured by FACS. In heterozygous humanized STING mice, active expression of human STING was detected in the heart and lung cells . 


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