hPSGL-1

Nomenclature

C57BL/6Smoc-Selplgem1(hSELPLG)Smoc

Cat. NO.

NM-HU-00046

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol
Selplg

Model Description

The endogenous mouse Selplg gene was replaced by human SELPLG gene.
Research Application:Immunotherapy,cancer research,drug screening

Validation Data

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Fig1. Detection of SELPLG expression in spleen by RT-PCR.Wild type:only one band at 539bp with primers F1/R1(mSelplg);Homozygous: only one band at 320bp with primers F2/R2(mSELPLG); Abbr:M,100bp Plus DNA ladder;HO, homozygous; HE, heterozygous; WT, wild type

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Fig2. Detection of hPSGL-1 expression on B cells in blood in hPSGL-1 knockin mice. 

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Fig3. Detection of hPSGL-1 expression on Monocytes and Granulocytes in blood in hPSGL-1 knockin mice. 

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Fig4. Detection of hPSGL-1 expression on B cells in bone morrow in hPSGL-1 knockin mice.

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Fig5. Detection of hPSGL-1 expression on Monocytes and Granulocytes in bone morrow in hPSGL-1 knockin mice.

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Fig6. Detection of hPSGL-1 expression on T cells in bone morrow in hPSGL-1 knockin mice.

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Fig7. Detection of hPSGL-1 expression on NKs and DCs in bone morrow in hPSGL-1 KI mice.

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Fig8. Detection of hPSGL-1 expression on B cells in spleen in hPSGL-1 knockin mice.

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Fig9. Detection of hPSGL-1 expression on Monocytes and Granulocytes in spleen in hPSGL-1 knockin mice.

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Fig10. Detection of hPSGL-1 expression on T cells in thymus in hPSGL-1 knockin mice.


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