hCTLA-4/hCD28(BALB/c)

Nomenclature

BALB/cAnSmoc-Ctla4em1(hCTLA4)Cd28em1(hCD28)Smoc

Cat. NO.

NM-HU-200226

Strain State

Sperm cryopreservation

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Gene Summary

Gene Symbol
CD28

Synonyms

NCBI ID

12487

MGI ID

88327

Ensembl ID

ENSMUSG00000026012

Pubmed

CD28

Human Ortholog

CD28

Gene Symbol
CTLA4

Synonyms

Cd152; Ly-56; Ctla-4

NCBI ID

12477

MGI ID

88556

Ensembl ID

ENSMUSG00000026011

Pubmed

CTLA4

Human Ortholog

CTLA4

Model Description

The endogenous mice Ctla4 and Cd28 gene was replaced by human CTLA4 and CD28 gene.
Research Application：Immunotherapy

Validation Data

2.png

Fig1. Analysis of human CTLA4(hCD152) expression in the spleen by FACS . The homozygous KI mouse expresses human CTLA4 on T cells.

3.png

Fig2. Analysis of human CD28 expression in the spleen by FACS . The homozygous KI mouse expresses human CD28 on T cells.

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