hSIRPA(2)/hCD47

Nomenclature

C57BL/6Smoc-Sirpatm2(hSIRPA)Cd47em1(hCD47)/Smoc

Cat. NO.

NM-HU-2000111

Strain State

Repository Live

Export PDF

Gene Summary

Gene Symbol
SIRPA

Synonyms

Bit; P84; SIRP; SHP-1; CD172a; Ptpns1; SHPS-1; AI835480

NCBI ID

19261

MGI ID

108563

Ensembl ID

ENSMUSG00000037902

Pubmed

SIRPA

Human Ortholog

SIRPA

Gene Symbol
CD47

Synonyms

IAP; Itgp

NCBI ID

16423

MGI ID

96617

Ensembl ID

ENSMUSG00000055447

Pubmed

CD47

Human Ortholog

CD47

Gene Symbol
CD47

Synonyms

IAP; Itgp; AA407862; AI848868; AW108519; 9130415E20Rik; B430305P08Rik

NCBI ID

16423

MGI ID

96617

Ensembl ID

ENSMUSG00000055447

Pubmed

CD47

Human Ortholog

CD47

Model Description

This SIRPA and CD47 double Knock-in strain is established by crossing hSIRPA and hCD47 mice together. These double double Knock-in mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.While hSIRPA/hCD47 (Stock No.NM-HU-190019) have been pulled from shelves for some reasons.
Research Application：Immunotherapy,cancer research,drug screening

Validation Data

image.png

Fig 1. Detection of m&hCD47 expression on T, B, NK cells in HO hSIRPA(2)/hCD47 mice.

image.png

Fig 2. Detection of m&hCD47 expression on erythrocytes and platelets in HO hSIRPA(2)/hCD47 mice.

image.png

Fig 3. Detection of m&hCD47 expression in PB sample in HO hSIRPA(2)/hCD47 mice.

image.png

Fig 4. Detection of m&hCD47 expression in spleen sample in HO hSIRPA(2)/hCD47 mice.

You may also like

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

Learn more
Customizing Mouse Models: Delivering in 100 Days to Speed Up Your Research!

At GenoBioTX, we understand that the lengthy wait times for gene-modified mouse models can hinder your research progress. Traditional methods often require 6-9 months, leading to delays and increased costs. That’s why we’re thrilled to introduce our innovative service designed to streamline this process and deliver results faster.

Learn more