hTREM2

Nomenclature

C57BL/6Smoc-Trem2em4(hTRem2)/Smoc

Cat. NO.

NM-HU-2000083

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol
Trem2

Synonyms

TREM-2; Trem2a; Trem2b; Trem2c

NCBI ID

83433

MGI ID

1913150

Ensembl ID

ENSMUSG00000023992

Pubmed

Trem2

Human Ortholog

TREM2

Model Description

The endogenous mouse Trem2 gene was replaced by human TREM2 gene.
Research Application：Alzheimer's disease research;drug screening

Validation Data

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Fig1. Detection of TREM2 expression in brain by RT-PCR. Wild type: only one band at 344 bp with primers F1/R1(mTrem2);Homoygous: only one band at 308 bp with primers F2/R2(hTREM2); Abbr.. M, DNA marker; HO, homozygous; HE, heterozygous; WT, wild type.

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Fig2. hTREM2 Expression in Tumor-infiltrating Macrophages in hTREM2 Mice Bearing MC38 Syngenic Tumors. (Anti-hTREM2 antibody provided by the third party)

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Fig3. hTREM2 Expression in Tumor-infiltrating Macrophages in hTREM2 Mice Bearing MC38 Syngenic Tumors. (The commercial Anti-hTREM2 antibody has cross reactivity with mouse TREM2)

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