hPSGL-1(2)

Nomenclature

C57BL/6Smoc-Selplgem2(hSELPLG)Smoc

Cat. NO.

NM-HU-210026

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol
Selplg

Synonyms

CD162; Psgl1; Selp1; Selpl; Psgl-1

NCBI ID

20345

MGI ID

106689

Ensembl ID

ENSMUSG00000048163

Pubmed

Selplg

Human Ortholog

SELPLG

Model Description

The endogenous mice Selplg gene was completely or partially replaced by human SELPLG gene via CRISPR/Cas9 mediated recombination.
Research Application：inmmue therapy；drug screening

Validation Data

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Fig1. Detection of PSGL-1 expression in thymus and spleen by RT-PCR. Wild type: only one band at 248 bp with primers F1/R1(mPsgl-1);Homozygous: only one band at 237 bp with primers F2/R2(hPSGL-1); Abbr.. M, DNA marker; HO, homozygous; HE, heterozygous; WT, wild type.

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Fig2. Detection of hPSGL-1 expression on B cells in blood in hPSGL-1 knockin mice.

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Fig3. Detection of hPSGL-1 expression on Monocytes and Granulocytes in blood in hPSGL-1 knockin mice.

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Fig4. Detection of hPSGL-1 expression on B cells in bone morrow in hPSGL-1 knockin mice.

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Fig5. Detection of hPSGL-1 expression on Monocytes and Granulocytes in bone morrow in hPSGL-1 knockin mice.

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Fig6. Detection of hPSGL-1 expression on T cells in bone morrow in hPSGL-1 knockin mice.

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Fig7. Detection of hPSGL-1 expression on NKs and DCs in bone morrow in hPSGL-1 KI mice.

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Fig8. Detection of hPSGL-1 expression on B cells in spleen in hPSGL-1 KI mice.

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Fig9. Detection of hPSGL-1 expression on Monocytes and Granulocytes in spleen in hPSGL-1 knockin mice.

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Fig10. Detection of hPSGL-1 expression on T cells in Thymus in hPSGL-1 knockin mice.

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