SMOC has developed a set of mouse models expressing humanized immune checkpoints. These models are suitable to assess the efficacy of drugs targeting immune checkpoints in fully immunocompetent mice.
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Strain Name：C57BL/6Smoc-Tigittm3(hTIGIT)Tnfrsf1bem2(hTNFRSF1B)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210371
Research Application：inmmue therapy;drug screening
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Strain Name：C57BL/6Smoc-Havcr2em1(hHAVCR2)/Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-00054
Research Application：Immunotherapy,cancer research,drug screening
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Strain Name：C57BL/6Smoc-Timd4tm1(hTIM4)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-HU-225042
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Strain Name：C57BL/6Smoc-Timd4em1(hTIMD4)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-HU-215055
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Strain Name：C57BL/6Smoc-Tlr2em2(hTLR2)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190066
Research Application：Immunotherapy,cancer research,drug screening
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Strain Name：C57BL/6Smoc-Tlr4em2(hTLR4)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000025
Research Application：Immunotherapy,drug screening
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Strain Name：C57BL/6Smoc-Tlr7tm1(hTLR7)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-18027
Research Application：Immunotherapy,Cancer research,Drug screening
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Strain Name：C57BL/6Smoc-Tlr8tm2(TLR8)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-190044
Research Application：Immunotherapy,cancer research,drug screening
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Strain Name：C57BL/6Smoc-Tlr8tm2(TLR8)Pdcd1em1(hPDCD1)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-200276
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Strain Name：C57BL/6Smoc-Lyz2em3(IRES-DTREGFP)Tlr8tm2(TLR8)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-200259
Research Application：tumor research；inmmue therapy；drug screening;myeloid cell-specific DTR mice
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