Chga-CreERT2

Nomenclature

C57BL/6Smoc-Chgaem(CreERT2-Wpre-pA)Smoc

Cat. NO.

NM-KI-204993

Strain State

Sperm cryopreservation

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Gene Summary

Gene Symbol
Chga

Synonyms

cgA; ChrA

NCBI ID

12652

MGI ID

88394

Ensembl ID

ENSMUSG00000021194

Pubmed

Chga

Human Ortholog

CHGA

Model Description

CreERT2-Wpre-pA expression cassette was knocked into the Chga gene.
Research Application：By mating the reporter mice with CreERT2-expressing mice, Chga positive cells derived from double-positive mice were permanently labeled by fluorescent protein after tamoxifen treatment. These mice may be useful in the research of hypertension, heart disease and enteritidis.

Validation Data

Chga-CreERT2-1.png

Fig. 1 Detection of tdTomato (red) in the pancreas of ChgaCreERT2/+; Rosa26tdTomato/+ mice after tamoxifen treatment. 

CreERT2-mediated recombination in the pancreas islet and some acinar cells can be induced by tamoxifen. 

Chga-CreERT2-3.png

Fig. 2 Detection of tdTomato (red) in various tissues of ChgaCreERT2/+; Rosa26tdTomato/+ mice after tamoxifen treatment. 

CreERT2-mediated recombination in some cells of the pancreas, lung, kidney and submandibular gland can be induced by tamoxifen. Some leakiness were detected in the brain, stomach, colon and intestine prior to tamoxifen exposure. Besides, tdtomato expression can not be detected in the liver, brown fat, spleen, muscle, skin, testis and epididymis. (For more detailed information please contact our technical advisor.)

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