Nmu-2A-Cre

Nomenclature

C57BL/6Smoc-Nmuem1(2A-Cre-WPRE-polyA)Smoc

Cat. NO.

NM-KI-200298

Strain State

Repository Live

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Gene Summary

Gene Symbol
Nmu

Synonyms

-

NCBI ID

56183

MGI ID

1860476

Ensembl ID

ENSMUSG00000029236

Pubmed

Nmu

Human Ortholog

NMU

Model Description

2A-Cre-WPRE-polyA expression cassette was knocked into the Nmu gene stop codon site. Nmu gene encodes a member of the neuromedin family of neuropeptides. The encoded protein plays a role in energy homeostasis and body temperature regulation. And the protein is homologous with human NMU, which is linked toobesity.
Research Application：Cre recombinase tool; Neuroscience

Validation Data

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Fig. 1 Cre-mediated recombination in the intestine of NmuCre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the submucosal plexus (red arrows) of NmuCre/+; Rosa26tdTomato/+ mouse.

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Fig. 2 Cre-mediated recombination in the intestine of NmuCre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the substantia nigra pars reticulate(SNR) of NmuCre/+; Rosa26tdTomato/+ mouse.

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Fig. 3 Detection of tdTomato(red) in various tissues of NmuCre/+; Rosa26tdTomato/+ mice. Cre-mediated recombination can be detected in some cells of the heart, intestine, colon, pancreas, ovary, uterus, thymus, stomach. Tdtomato can also be detected in individual cells of the brown fat, kidney, lung, liver, muscle, salivary gland, skin and spleen. (For more detailed information please contact our technical advisor.)


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