Anxa10-2A-CreERT2

Nomenclature

C57BL/6Smoc-Anxa10em1(2A-CreERT2-Wpre-pA)Smoc

Cat. NO.

NM-KI-200312

Strain State

Repository Live

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Gene Summary

Gene Symbol
Anxa10

Synonyms

NCBI ID

26359

MGI ID

1347090

Ensembl ID

ENSMUSG00000031635

Pubmed

Anxa10

Human Ortholog

ANXA10

Model Description

2A-CreERT2-Wpre-pA expression cassette was knocked into the Anxa10 gene stop codon site.
Research Application：These mice express tamoxifen induced cre recombinase from the Anxa10 locus. By mating the reporter mice with CreERT2-expressing mice, reporter gene expression can be detected in gastric mucosa epithelial cells after tamoxifen treatment. And the mice are useful for generating conditional mutations in gastric mucosa epithelial cells. This strain may useful for in the research of gastric carcinoma.

Validation Data

Anxa10-2A-CreERT2-1.png

Fig.1 CreERT2-mediated recombination in the stomach of Anxa10CreERT2/+ ; Rosa26tdTomato/+ mouse. 

TdTomato(red) expression can be detected in the gastric mucosal epithelial cell of Anxa10CreERT2/+; Rosa26tdTomato/+ mouse after tamoxifen treatment. 

Anxa10-2A-CreERT2-2.png

Fig.2 Detection of tdTomato (red) in various tissues of Anxa10CreERT2/+; Rosa26tdTomato/+ mice after tamoxifen treatment. 

CreERT2-mediated recombination in the gastric mucosal cells and hair follicle cells can be induced by tamoxifen. A small degree of leakiness were detected in the thymus prior to tamoxifen exposure. Besides, tdtomato expression can not be detected in the brain, eyes, heart, lung, liver, submandibular gland, kidney, ovary, uterus, intestine, colon, spleen, brown fat, and muscle. (For more detailed information please contact our technical advisor.)

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