Tagln-Cre

Nomenclature

C57BL/6Smoc-Taglnem1(Cre-WPRE-polyA)Smoc

Cat. NO.

NM-KI-200144

Strain State

Repository Live

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Gene Summary

Gene Symbol

Synonyms

Sm22， Sm22a， Ws310

NCBI ID

21345

MGI ID

106012

Ensembl ID

ENSMUSG00000032085

Pubmed

Human Ortholog

TAGLN

Model Description

A Cre-WPRE-polyA expression cassette was knocked into the Tagln gene start codon site. This gene encodes a smooth muscle cell-specific cytoskeletal protein. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in vascular smooth muscle cells. In mouse models of atherosclerosis, the gene product may be involved in plaque cell and atherosclerotic lesion formation during atherogenesis.
Research Application：Cre recombinase tool

Validation Data

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Fig. 1 Cre-mediated recombination in the embryo of TaglnCre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the vessels of E11.5 TaglnCre/+; Rosa26tdTomato/+ mouse embryo.

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Fig. 2 Cre-mediated recombination in the lung of TaglnCre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the pulmonary vascular smooth muscle cells of TaglnCre/+; Rosa26tdTomato/+ mouse.

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Fig. 3 Detection of tdTomato(red) in various tissues of TaglnCre/+; Rosa26tdTomato/+ mice. Tdtomato was abundantly expressed in the brain, eyes, heart, liver, lung, muscle, pancreas, testis, epididymis, salivary gland, spleen and thymus. Tdtomato was also detected in some cells of the colon, intestine, kidney, skin and in individual cells of brown fat and stomach. (For more detailed information please contact our technical advisor.)


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