Glp1r-IRES-Cre

Nomenclature

C57BL/6Smoc-Glp1rem1(IRES-iCre)Smoc

Cat. NO.

NM-KI-200134

Strain State

Sperm cryopreservation

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Gene Summary

Gene Symbol
Glp1r

Synonyms

GLP-1R; GLP1Rc

NCBI ID

14652

MGI ID

99571

Ensembl ID

ENSMUSG00000024027

Pubmed

Glp1r

Human Ortholog

GLP1R

Model Description

A IRES-iCre expression cassette was knocked into the Glp1r gene stop codon site.
Research Application：Cre recombinase tool; When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing cre. GLP1R encodes a receptor present on many cell types including pancreatic β cells, subsets of neurons in the central nervous system, as well as a subset of vagal sensory neurons in the gastrointestinal tract.

Validation Data

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Fig. 1 Cre-mediated recombination in the small intestine of Glp1rCre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the muscular layer of the wall of the small intestine derived from Glp1rCre/+; Rosa26tdTomato/+ mouse.

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Fig. 2 Cre-mediated recombination in the pancreas of Glp1rCre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the acinar and islet cells of Glp1rCre/+; Rosa26tdTomato/+ mouse.

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Fig. 3 Cre-mediated recombination in the brain of Glp1rCre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in individual cells of olfactory bulb, cortex, interbrain, thalamus and hypothalamus derived from Glp1rCre/+; Rosa26tdTomato/+ mouse.

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Fig. 4 Detection of tdTomato(red) in various tissues of Glp1rCre/+; Rosa26tdTomato/+ mice. Cre mediated recombination can be detected in some cells of pancreas. TdTomato can also be detected in individual cells of the brain, intestine, colon, heart, lung, liver, stomach, submandibular gland, testis, epididymis, skin, skeletal muscle and spleen. Tdtomato expression can not be observed in the brown fat, thymus or retina. (For more detailed information please contact our technical advisor.)


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