Scgb1a1-IRES-CreERT2

Nomenclature

C57BL/6Smoc-Scgb1a1em1(IRES-CreERT2)Smoc

Cat. NO.

NM-KI-200129

Strain State

Repository Live

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Gene Summary

Gene Symbol
Scgb1a1

Synonyms

UG; UGB; Utg; CC10; CC16; CCSP; PCB-BP

NCBI ID

22287

MGI ID

98919

Ensembl ID

ENSMUSG00000024653

Pubmed

Scgb1a1

Human Ortholog

SCGB1A1

Model Description

A IRES-CreERT2 expression cassette was knocked into the Scgb1a1 gene stop codon site.
Research Application：These mice express creERT2 recombinase from the Scgb1a1 locus (secretoglobin). This strain may useful for in the research of bronchiolar non-ciliated Clara cells.

Validation Data

NM-KI-200129 Scgb1a1-IRES-CreERT2-1.png

Fig.1 CreERT2-mediated recombination in the lung of  Scgb1a1CreERT2/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the bronchial and alveolar cells of  Scgb1a1CreERT2/+; Rosa26tdTomato/+ mouse after tamoxifen treatment. 

NM-KI-200129 Scgb1a1-IRES-CreERT2-2.png

Fig. 2 Detection of tdTomato(red) in various tissues of Scgb1a1CreERT2/+; Rosa26tdTomato/+ mice. CreERT2 mediated recombination can be detected in the bronchial and alveolar cells after tamoxifen treatment. TdTomato expression can not be observed in the brain, pituitary gland, heart, liver, spleen, kidney, thymus, stomach, intestine, colon, submandibular gland, ovary, uterus, skin, muscle and brown fat. (For more detailed information please contact our technical advisor.)


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