Isl1-Cre

Nomenclature

C57BL/6Smoc-Isl1em1(iCre-WPRE-pA)Smoc

Cat. NO.

NM-KI-200126

Strain State

Sperm cryopreservation

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Gene Summary

Gene Symbol
Isl1

Synonyms

-

NCBI ID

16392

MGI ID

101791

Ensembl ID

ENSMUSG00000042258

Pubmed

Isl1

Human Ortholog

ISL1

Model Description

A iCre-WPRE-pA expression cassette was knocked into the Isl1 gene start codon site.
Research Application：Cre recombinase tool; Isl1-Cre mice express Cre recombinase under the control of the ISL1 transcription factor. It can be used for lineage tracing of Isl1 positive cells.

Validation Data

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Fig. 1 Cre-mediated recombination in the retina of IslCreERT2 /+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the retinal ganglion cell layer (RGC) and inner nuclear layer (INL) of IslCre/+; Rosa26tdTomato/+ mouse.

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Fig. 2 Cre-mediated recombination in the pancreas of IslCre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the acinar cells and islet cells derived from IslCre/+; Rosa26tdTomato/+ mouse.

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Fig. 3 Detection of tdTomato(red) in various tissues of IslCre/+; Rosa26tdTomato/+ mice. Cre mediated recombination can be detected in the retina, pancreas, heart, brain, pituitary gland, lung, liver, stomach, submandibular gland, brown fat, kidney, intestine, colon, spleen, thymus, testis and epididymis. (For more detailed information please contact our technical advisor.)


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