Myf6-CreERT2

Nomenclature

C57BL/6Smoc-Myf6em1(CreERT2-pA)Smoc

Cat. NO.

NM-KI-200125

Strain State

Repository Live

Export PDF

Gene Summary

Gene Symbol
Myf6

Synonyms

MRF4; bHLHc4; herculin

NCBI ID

17878

MGI ID

97253

Ensembl ID

ENSMUSG00000035923

Pubmed

Myf6

Human Ortholog

MYF6

Model Description

A CreERT2-pA expression cassette was knocked into the Myf6 gene start codon site. Myf6 (myogenic factor 6) is a DNA-binding protein involved in muscle development. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing Myf6.
Research Application：Cre recombinase tool

Validation Data

image.png

Fig. 1 CreERT2-mediated recombination in the muscle of Myf6CreERT2/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the muscle of Myf6CreERT2/+; Rosa26tdTomato/+ mouse after tamoxifen treatment.

myf6.png

Fig. 2 Detection of tdTomato(red) in various tissues of Myf6CreERT2/+; Rosa26tdTomato/+ mice. Tdtomato is expressed in the muscle and thymus after tamoxifen treatment. Tdtomato expression can not be observed in the brain, colon, epididymis, kidney, spleen, stomach, brown fat, intestine, heart, retina, liver, lung, pancreas, testis and salivary gland. (For more detailed information please contact our technical advisor.)

 


Publications

α-myosin heavy chain lactylation maintains sarcomeric structure and function and alleviates the development of heart failure
References：Cell Research

You may also like

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

Learn more
Customizing Mouse Models: Delivering in 100 Days to Speed Up Your Research!

At GenoBioTX, we understand that the lengthy wait times for gene-modified mouse models can hinder your research progress. Traditional methods often require 6-9 months, leading to delays and increased costs. That’s why we’re thrilled to introduce our innovative service designed to streamline this process and deliver results faster.

Learn more