Notch1-CreERT2

Nomenclature

C57BL/6Smoc-Notch1em1(CreERT2-2xpA)Smoc

Cat. NO.

NM-KI-200122

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol
Notch1

Synonyms

N1; Mis6; Tan1; lin-12; 9930111A19Rik

NCBI ID

18128

MGI ID

97363

Ensembl ID

ENSMUSG00000026923

Pubmed

Notch1

Human Ortholog

NOTCH1

Model Description

A CreERT2-2xpA expression cassette was knocked into the Notch1 gene start codon site. Notch1 performs vital cell functions, such as proliferation, differentiation, apoptosis, and stem cell maintenance. When Notch1-CreERT2 mice are bred with mice containing loxP-flanked sequence, tamoxifen-inducible, Cre-mediated recombination will result in deletion of the floxed sequences in NOTCH1 positive cells.
Research Application：Cre recombinase tool;

Validation Data

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Fig. 1 CreERT2-mediated recombination in individual cells of small intestinal derived from Notch1-CreERT2; Rosa26-tdTomato mice after tamoxifen treatment.

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Fig. 2 CreERT2-mediated recombination in individual cells of liver derived from Notch1-CreERT2; Rosa26-tdTomato mice after tamoxifen treatment.

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Fig. 3 Labeling was also observed in individual cells of the brain, heart, brown fat, salivary gland, lung, liver, stomach, kidney, pancreas, epidermis, colon, spleen, thymus and muscle.(For more information please contact: 400-728-0660.)


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