Prox1-IRES-CreERT2

Nomenclature

C57BL/6Smoc-Prox1em1(IRES-CreERT2-pA)Smoc

Cat. NO.

NM-KI-200119

Strain State

Repository Live

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Gene Summary

Gene Symbol
Prox1

Synonyms

A230003G05Rik

NCBI ID

19130

MGI ID

97772

Ensembl ID

ENSMUSG00000010175

Pubmed

Prox1

Human Ortholog

PROX1

Model Description

A IRES-CreERT2-pA expression cassette was knocked into the Prox1 gene stop codon site. Prox1 encodes a transcription factor (prospero-related homeobox 1) that is necessary for the formation and maintenance of lymphatic vessels. When Prox1-IRES-CreERT2 mice are bred with mice containing loxP-flanked sequence, tamoxifen-inducible Cre-mediated recombination will result in deletion of the floxed sequences in PROX1positive cells.
Research Application：Cre recombinase tool; Neuroscience

Validation Data

image.png

Fig1. CreERT2-mediated recombination in Dentate Gyrus of Prox1CreERT2/+;Rosa26tdTomato/+  mouse.image.png

Fig2. CreERT2-mediated recombination in Small intestine of Prox1CreERT2/+;Rosa26tdTomato/+ mouse. image.png

Fig3. Detection of tdTomato(red) in various tissues of Prox1CreERT2/+;Rosa26tdTomato/+ mice. Labeling was also observed in pituitary gland, retina, heart, thymus, stomach, lung, submandibular gland, muscle, ovary, spleen, pancreas and kidney. (For more information please contact: 400-728-0660.)

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