Slc6a4-Cre

Nomenclature

C57BL/6Smoc-Slc6a4em1(iCre-pA)Smoc

Cat. NO.

NM-KI-200115

Strain State

Sperm cryopreservation

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Gene Summary

Gene Symbol
Slc6a4

Synonyms

Htt; Sert; 5-HTT; AI323329

NCBI ID

15567

MGI ID

96285

Ensembl ID

ENSMUSG00000020838

Pubmed

Slc6a4

Human Ortholog

SLC6A4

Model Description

A iCre-pA expression cassette was knocked into the Slc6a4 gene start codon site. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing Cre. The gene product has been involved in the neurological disorders such as addiction and depression.
Research Application：Cre recombinase tool

Validation Data

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Fig. 1 Cre-mediated recombination in the brain of Slc6a4Cre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the cortex, thalamus and olfactory bulb of Slc6a4Cre/+; Rosa26tdTomato/+ mouse.

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Fig. 2 Detection of tdTomato(red) in various tissues of Slc6a4Cre/+; Rosa26tdTomato/+ mice. Tdtomato expression can be detected in the cortex, thalamus, heart, bronchi, liver, stomach, salivary gland, skin, testis, kidney, thymus, spleen, pancreas, intestine and colon. Tdtomato expression can not be detected in the retina or muscle. (For more detailed information please contact our technical advisor.)


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