Foxn1-IRES-Cre

Nomenclature

C57BL/6Smoc-Foxn1em1(IRES-iCre)Smoc

Cat. NO.

NM-KI-200106

Strain State

Sperm cryopreservation

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Gene Summary

Gene Symbol
Foxn1

Synonyms

nu; Whn; nude; Fkh19; Hfh11; HFH-11; D11Bhm185e

NCBI ID

15218

MGI ID

102949

Ensembl ID

ENSMUSG00000002057

Pubmed

Foxn1

Human Ortholog

FOXN1

Model Description

A IRES-iCre expression cassette was knocked into the Foxn1 gene stop codon site. The protein encoded by Foxn1 (forkhead box N1) gene is part of the forkhead family or transcription factors that are important in developmental processes, immune system regulation, metabolism, cancer and aging. When crossed with a strain carrying a gene flanked by sites, the flanked gene will be removed in thymic epithelial cell and keratinocytes.
Research Application：Cre recombinase tool; Thymus-related research

Validation Data

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Fig. 1 Cre-mediated recombination in the thymus of Foxn1Cre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the thymus of Foxn1Cre/+; Rosa26tdTomato/+ mouse.

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Fig. 2 Detection of tdTomato(red) in various tissues of Foxn1Cre/+; Rosa26tdTomato/+ mice. Cre-mediated recombination can be detected in some cells of the thymus, skin, stomach, uterus and in individual cells of the colon, eye, kidney, lung, pancreas. Tdtomato can not be detected in the brain, muscle, heart, liver, ovary, intestine or spleen. (For more detailed information please contact our technical advisor.)


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