Pdyn-IRES-Cre

Nomenclature

C57BL/6Smoc-Pdynem1(IRES-iCre)Smoc

Cat. NO.

NM-KI-200089

Strain State

Sperm cryopreservation

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Gene Summary

Gene Symbol
Pdyn

Synonyms

Dyn

NCBI ID

18610

MGI ID

97535

Ensembl ID

ENSMUSG00000027400

Pubmed

Pdyn

Human Ortholog

PDYN

Model Description

A IRES-iCre expression cassette was knocked into the Pdyn gene stop codon site. Pdyn encodes prodynorphin. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing cre. This strain may be useful for studying depression, stress, anxiety, pain response, circadian rhythm and appetite control.
Research Application：Cre recombinase tool; Neuroscience

Validation Data

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Fig. 1 Cre-mediated recombination in the brain of PdynCre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the cortex, hippocampus and striatum of PdynCre/+; Rosa26tdTomato/+ mouse.

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Fig. 2 Detection of tdTomato(red) in various tissues of  PdynCre/+; Rosa26tdTomato/+ mice. Cre mediated recombination can be detected in some cells of the brain, kidney, pancreas islet, heart, liver, lung, stomach, brown fat, intestine, colon, ovary, thymus and spleen. Tdtomato expression can not be observed in the salivary gland, skin or muscle. (For more detailed information please contact our technical advisor.)


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