Gja1-2A-DreERT2

Nomenclature

C57BL/6Smoc-Gja1em1(2A-DreERT2）Smoc

Cat. NO.

NM-KI-200026

Strain State

Sperm cryopreservation

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Gene Summary

Gene Symbol
Gja1

Synonyms

Cx43; Npm1; Cnx43; Gja-1; AU042049; AW546267; Cx43alpha1; connexin43

NCBI ID

14609

MGI ID

95713

Ensembl ID

ENSMUSG00000050953

Pubmed

Gja1

Human Ortholog

GJA1

Model Description

A 2A-DreERT2 expression cassette was knocked into the Gja1 gene stop codon site via CRISPR/Cas9 mediated recombination.
Research Application：Dre recombinase tool

Validation Data

image.png

Fig.1 DreERT2-mediated recombination in the adipose tissue of Gja1DreERT2/+；R26tdTomato/+ mouse. TdTomato (red) expression can be detected in the adipose tissue after tamoxifen treatment. Connexin 43 (Cx43, encoded by Gja1, green) is a cell-cell communication gap junction protein expressed in adipose tissue. (Documented in the following reference.)


Publications

A Suite of New Dre-recombinase Drivers Markedly Expands the Ability to Perform Intersectional Genetic Targeting
References：CELL STEM CELL

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