Dmpk-KO

Nomenclature

C57BL/6Smoc-Dmpkem1Smoc

Cat. NO.

NM-KO-200635

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol
Dmpk

Synonyms

DM; DMK; Dm15; MDPK; MT-PK

NCBI ID

13400

MGI ID

94906

Ensembl ID

ENSMUSG00000030409

Pubmed

Dmpk

Human Ortholog

DMPK

Model Description

Exon 1-7 of Dmpk gene was deleted to generate Dmpk knockout mice.
Research Application：Cardiac conduction and G protein signal transduction RAC1 in cellular processes

Disease Connection

Myotonic Dystrophy Type 1

Phenotype(s)

MGI:3613697

Reference(s)

Reddy S, Smith DB, Rich MM, Leferovich JM, Reilly P, Davis BM, Tran K, Rayburn H, Bronson R, Cros D, Balice-Gordon RJ, Housman D, Mice lacking the myotonic dystrophy protein kinase develop a late onset progressive myopathy [see comments]. Nat Genet. 1996 Jul;13(3):325-35

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