Lat-Y136F

Nomenclature

C57BL/6Smoc-Latem1(Y136F）Smoc

Cat. NO.

NM-KI-200249

Strain State

Repository Live

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Gene Summary

Gene Symbol
Lat

Synonyms

pp36; p36-38

NCBI ID

16797

MGI ID

1342293

Ensembl ID

ENSMUSG00000030742

Pubmed

Lat

Human Ortholog

LAT

Model Description

These mice carry a p.Y136F mutation of Lat gene.
Research Application：IgG4-related diseases

Disease Connection

Igg4-Related Disease

Phenotype(s)

MGI:2385971

Reference(s)

Aguado E, et al., Induction of T helper type 2 immunity by a point mutation in the LAT adaptor. Science. 2002 Jun 14;296(5575):2036-40

Validation Data

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Fig1. Spleen (left) and mesenteric lymph nodes (right) from 8-week-old wild-type and Lat-Y136F mice.

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Fig2. Immunotype in Lat-Y136F mice in lymph nodes.

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Fig3. Immunotype in Lat-Y136F mice in peripheral blood.

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Fig4. Immunotype in Lat-Y136F mice in spleen.

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Fig5. Immunotype in Lat-Y136F mice in thymus.

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Fig6. Analysis of mIgE expression in the serum by ELISA in WT C57BL/6 and HO Lat-Y136F mice (female, 8-9wks, n=5). 

The expression of mIgE in the serum increased significantly in the homozygous KI mouse.

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Fig7. Analysis of mIgG1 expression in the serum by ELISA in WT C57BL/6 and HO Lat-Y136F mice (female, 8-9wks, n=5). 

The expression of mIgG1 in the serum increased significantly in the homozygous KI mouse.

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