hHBB

Nomenclature

C57BL/6Smoc-Hbb-bt&Hbb-bstm1(hHBB)/Smoc

Cat. NO.

NM-HU-2000080

Strain State

Repository Live

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Gene Summary

Gene Symbol
Hbb-bt

Gene Symbol
Hbb-bs

Model Description

The endogenous mouse Hbb-bt and Hbb-bs gene was replaced by human HBB gene.

Research Application:Thalassemia research;drug screening

Validation Data

image.png

Fig.1 Detection of HBB expression in spleen by RT-PCR. 

Wild type: one band at 139 bp with primers F1/R1(mHbb-bt/Hbb-bs) and one band at 178 bp with primers F2/R2(mHbb-bs/Hbb-bt);

Homozygous: only one band at 162 bp with primers F3/R3(hHBB).

Abbr. M, DNA marker; HO, homozygous; WT, wild type.

image.png

Fig.2 Detection of human HBB expression in hHBB mice by WB. 

Abbr. M, marker; WT, wild type; HO, Homozygous.


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