Gla-KO

Nomenclature

C57BL/6Smoc-Glaem1Smoc

Cat. NO.

NM-KO-200601

Strain State

Repository Live

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Gene Summary

Gene Symbol
Gla

Model Description

Exon 2-3 of Gla gene was deleted to generate Gla knockout mice.
Research Application:Fabry Disease research

Disease Connection

Fabry Disease

Validation Data

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Fig1. Detection of Gla expression in brain by RT-PCR (A) and qPCR (B). 

Wild type: only one band at 268 bp with primers F1/R1(mGla).

Abbr. M, DNA marker; WT, wild type.

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Fig2. Detection of serum GLA activity (A) and serum lyso-Gb3 levels (B) in 14 weeks old male Gla-KO mice. (Data from the collaborator)

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Fig3. Hot plate test of 14 weeks old male Gla-KO mice. (Data from the collaborator)


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