Flvcr1-Flox

Nomenclature

C57BL/6Smoc-Flvcr1em1(flox)Smoc

Cat. NO.

NM-CKO-200054

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol
Flvcr1

Synonyms

FLVCR， Mfsd7b， 9630055N22Rik

NCBI ID

226844

MGI ID

2444881

Ensembl ID

ENSMUSG00000066595

Pubmed

Flvcr1

Human Ortholog

FLVCR1

Model Description

These mice carry loxP sites flanking exon 3 of Flvcr1 gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Flvcr1 gene.
Research Application：Diseases associated with FLVCR1 include Posterior Column Ataxia With Retinitis Pigmentosa and Posterior Column Ataxia.

Disease Connection

Diamond-Blackfan Anemia

Phenotype(s)

MGI:3807529
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Mx1-cre mice.

Reference(s)

Keel SB, Doty RT, Yang Z, Quigley JG, Chen J, Knoblaugh S, Kingsley PD, De Domenico I, Vaughn MB, Kaplan J, Palis J, Abkowitz JL, A heme export protein is required for red blood cell differentiation and iron homeostasis. Science. 2008 Feb 8;319(5864):825-8

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