Fas-KO(BALB/c)

Nomenclature

BALB/cAnSmoc-Fasem2Smoc

Cat. NO.

NM-KO-191206

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol
Fas

Synonyms

lpr， APO1， APT1， CD95， TNFR6， Tnfrsf6， AI196731

NCBI ID

14102

MGI ID

95484

Ensembl ID

ENSMUSG00000024778

Pubmed

Fas

Human Ortholog

FAS

Model Description

Exon 2 of Fas gene was deleted to generate Fas knockout mice.
Research Application：Immune-related

Disease Connection

Systemic Lupus Erythematosus

Phenotype(s)

MGI:3800222
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Tnfrsf9-KO(2)(NM-KO-210216) mice.

Reference(s)

Ohta A, Sekimoto M, Sato M, Koda T, Nishimura S, Iwakura Y, Sekikawa K, Nishimura T, Indispensable role for TNF-alpha and IFN-gamma at the effector phase of liver injury mediated by Th1 cells specific to hepatitis B virus surface antigen. J Immunol. 2000 Jul 15;165(2):956-61

Systemic Lupus Erythematosus

Phenotype(s)

MGI:5478500
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Tlr9-KO(NM-KO-190168) mice.

Reference(s)

Christensen SR, Shupe J, Nickerson K, Kashgarian M, Flavell RA, Shlomchik MJ, Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus. Immunity. 2006 Sep;25(3):417-28

Membranous Glomerulonephritis

Phenotype(s)

MGI:4943704
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Il27ra-KO(NM-KO-190496) mice.

Reference(s)

Shimizu S, Sugiyama N, Masutani K, Sadanaga A, Miyazaki Y, Inoue Y, Akahoshi M, Katafuchi R, Hirakata H, Harada M, Hamano S, Nakashima H, Yoshida H, Membranous glomerulonephritis development with Th2-type immune deviations in MRL/lpr mice deficient for IL-27 receptor (WSX-1). J Immunol. 2005 Dec 1;175(11):7185-92

Systemic Lupus Erythematosus

Phenotype(s)

MGI:3665495
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Ccr2-KO(NM-KO-190018) mice.

Reference(s)

de Lema GP, Maier H, Franz TJ, Escribese M, Chilla S, Segerer S, Camarasa N, Schmid H, Banas B, Kalaydjiev S, Busch DH, Pfeffer K, Mampaso F, Schlondorff D, Luckow B, Chemokine receptor Ccr2 deficiency reduces renal disease and prolongs survival in MRL/lpr lupus-prone mice. J Am Soc Nephrol. 2005 Dec;16(12):3592-601

Autoimmune Lymphoproliferative Syndrome

Phenotype(s)

MGI:2450098

Reference(s)

Adachi M, SuematsuS, Suda T, Watanabe D, FukuyamaH, Ogasawara J, Tanaka T, Yoshida N, Nagata S, Enhanced and accelerated lymphoproliferation in Fas-null mice. Proc Natl Acad Sci U S A. 1996 Mar 5;93(5):2131-6

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