Lepr-KO

Nomenclature

C57BL/6Smoc-Leprem1Smoc

Cat. NO.

NM-KO-190663

Strain State

Sperm cryopreservation

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Gene Summary

Gene Symbol
Lepr

Synonyms

db; Obr; obl; Leprb; Modb1; LEPROT; OB-RGRP; diabetes; obese-like

NCBI ID

16847

MGI ID

104993

Ensembl ID

ENSMUSG00000057722

Pubmed

Lepr

Human Ortholog

LEPR

Model Description

Exon 5 of Lepr gene was deleted to generate Lepr knockout mice.
Research Application：obesity

Disease Connection

Type 2 Diabetes Mellitus

Phenotype(s)

MGI:5620891

Reference(s)

Lee Y, Berglund ED, Yu X, Wang MY, Evans MR, Scherer PE, Holland WL, Charron MJ, Roth MG, Unger RH, Hyperglycemia in rodent models of type 2 diabetes requires insulin-resistant alpha cells. Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13217-22

Obesity

Phenotype(s)

MGI:3511748

Reference(s)

McMinn JE, Liu SM, Dragatsis I, Dietrich P, Ludwig T, Eiden S, Chua SC Jr, An allelic series for the leptin receptor gene generated by CRE and FLP recombinase. Mamm Genome. 2004 Sep;15(9):677-85

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