Eif4ebp2-KO

Nomenclature

C57BL/6Smoc-Eif4Ebp2em1Smoc

Cat. NO.

NM-KO-191121

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol
Eif4ebp2

Synonyms

4E-BP2， PHAS-II， AA792569， BC010348， 2810011I19Rik

NCBI ID

13688

MGI ID

109198

Ensembl ID

ENSMUSG00000020091

Pubmed

Eif4ebp2

Human Ortholog

EIF4EBP2

Model Description

Exon 3-4 of Eif4ebp2 gene was deleted to generate Eif4ebp2 knockout mice.
Research Application：Cell proliferation and differentiation, viral infection, nervous system, synaptic transmission, autism, muscle homeostasis

Disease Connection

Autism Spectrum Disorder

Phenotype(s)

MGI:3610950

Reference(s)

Gkogkas CG, Khoutorsky A, Ran I, Rampakakis E, Nevarko T, Weatherill DB, Vasuta C, Yee S, Truitt M, Dallaire P, Major F, Lasko P, Ruggero D, Nader K, Lacaille JC, Sonenberg N, Autism-related deficits via dysregulated eIF4E-dependent translational control. Nature. 2013 Jan 17;493(7432):371-7

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