Irs1-KO

Nomenclature

C57BL/6Smoc-Irs1em1Smoc

Cat. NO.

NM-KO-190827

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol
Irs1

Synonyms

G972R， IRS-1

NCBI ID

16367

MGI ID

99454

Ensembl ID

ENSMUSG00000055980

Pubmed

Irs1

Human Ortholog

IRS1

Model Description

Exon 1 of Irs1 gene was deleted to generate Irs1 knockout mice.
Research Application：diabetes related

Disease Connection

Type 2 Diabetes Mellitus

Phenotype(s)

MGI:2174965

Reference(s)

Tamemoto H, Kadowaki T, Tobe K, Yagi T, Sakura H, Hayakawa T, Terauchi Y, Ueki K, Kaburagi Y, Satoh S, Sekihara H, Yoshioka S, Horikoshi H, Furuta Y, Ikawa Y, Kasuga M, Yazaki Y, Aizawa S, Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1 [see comments]. Nature. 1994 Nov 10;372(6502):182-6

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