Hif1a-Flox

Nomenclature

C57BL/6Smoc-Hif1atm1(flox)Smoc

Cat. NO.

NM-CKO-190065

Strain State

Repository Live

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Gene Summary

Gene Symbol
Hif1a

Synonyms

MOP1; bHLHe78; AA959795; HIF1alpha; HIF1-alpha; HIF-1-alpha

NCBI ID

15251

MGI ID

106918

Ensembl ID

ENSMUSG00000021109

Pubmed

Hif1a

Human Ortholog

HIF1A

Model Description

These mice carry loxP sites flanking exon 2 of Hif1a gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Hif1a gene.
Research Application：Hypoxia-inducible factor 1-alpha,Metabolism and cancer research

Disease Connection

Von Hippel-Lindau Disease

Phenotype(s)

MGI:3621461
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Vhl-Flox(2)(NM-CKO-200232) and Pck1-cre mice.

Reference(s)

Rankin EB, Higgins DF, Walisser JA, Johnson RS, Bradfield CA, Haase VH, Inactivation of the arylhydrocarbon receptor nuclear translocator (Arnt) suppresses von Hippel-Lindau disease-associated vascular tumors in mice. Mol Cell Biol. 2005 Apr;25(8):3163-72

Glycogen Storage Disease Vii

Phenotype(s)

MGI:3621470
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Ckmm-cre mice.

Reference(s)

Mason SD, Howlett RA, Kim MJ, Olfert IM, Hogan MC, McNulty W, Hickey RP, Wagner PD, Kahn CR, Giordano FJ, Johnson RS, Loss of skeletal muscle HIF-1alpha results in altered exercise endurance. PLoS Biol. 2004 Oct;2(10):e288

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