Ldlr-KO(2)

Nomenclature

C57BL/6Smoc-Ldlrem1Smoc

Cat. NO.

NM-KO-210198

Strain State

Repository Live

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Gene Summary

Gene Symbol
Ldlr

Synonyms

Hlb301

NCBI ID

16835

MGI ID

96765

Ensembl ID

ENSMUSG00000032193

Pubmed

Ldlr

Human Ortholog

LDLR

Model Description

Ldlr-KO(2) mice(Stock No.NM-KO-210198) carry a knockout allele derived from the targeted deletion of exon 4. While Ldlr-KO mice(Stock No.NM-KO-190559) carrying the exon 6-10 deletion.

Disease Connection

familial hypercholesterolemia

Phenotype(s)

MGI:3691620

Reference(s)

Jones C, Hammer RE, Li WP, Cohen JC, Hobbs HH, Herz J, Normal sorting but defective endocytosis of the low density lipoprotein receptor in mice with autosomal recessive hypercholesterolemia. J Biol Chem. 2003 Aug 1;278(31):29024-30

Fatty Liver Disease

Phenotype(s)

MGI:3611043

Reference(s)

Subramanian S, Goodspeed L, Wang S, Kim J, Zeng L, Ioannou GN, Haigh WG, Yeh MM, Kowdley KV, O'Brien KD, Pennathur S, Chait A, Dietary cholesterol exacerbates hepatic steatosis and inflammation in obese LDL receptor-deficient mice. J Lipid Res. 2011 Sep;52(9):1626-35

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