Pd-1-KO

Nomenclature

C57BL/6Smoc-Pdcd1em3Smoc

Cat. NO.

NM-KO-190423

Strain State

Repository Live

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Gene Summary

Gene Symbol
Pdcd1

Synonyms

PD-1 Pdc1 Ly101

NCBI ID

18566

MGI ID

104879

Ensembl ID

ENSMUSG00000026285

Pubmed

Pdcd1

Human Ortholog

PDCD1

Model Description

The Pdcd1 knockout mouse model was generated by knocking out the exon2-4 region of the Pdcd1.
Research Application：Immune-related

Disease Connection

Cystitis

Phenotype(s)

MGI:5574062
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Fcgr2b-KO(3)(NM-KO-210279) mice.

Reference(s)

Sugino Y, Nishikawa N, Yoshimura K, Kuno S, Hayashi Y, Yoshimura N, Okazaki T, Kanematsu A, Ogawa O, BALB/c-Fcgr2bPdcd1 mouse expressing anti-urothelial antibody is a novel model of autoimmune cystitis. Sci Rep. 2012;2:317

Dilated Cardiomyopathy

Phenotype(s)

MGI:3054645

Reference(s)

Nishimura H, Okazaki T, Tanaka Y, Nakatani K, Hara M, Matsumori A, Sasayama S, Mizoguchi A, Hiai H, Minato N, Honjo T, Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice. Science. 2001 Jan 12;291(5502):319-22

Systemic Lupus Erythematosus

Phenotype(s)

MGI:3054643

Reference(s)

Nishimura H, Minato N, Nakano T, Honjo T, Immunological studies on PD-1 deficient mice: implication of PD-1 as a negative regulator for B cell responses. Int Immunol. 1998 Oct;10(10):1563-72

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