Alpl-KO

Nomenclature

C57BL/6Smoc-Alpltm1Smoc

Cat. NO.

NM-KO-18058

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol
Alpl

Synonyms

ALP; Akp2; TNAP; Akp-2; APTNAP; TNSALP

NCBI ID

11647

MGI ID

87983

Ensembl ID

ENSMUSG00000028766

Pubmed

Alpl

Human Ortholog

ALPL

Model Description

This Alpl knockout mouse model was obtained by knocking out the exon 3-4 region of the Alpl gene.

Disease Connection

Childhood Hypophosphatasia

Phenotype(s)

MGI:2174902

Reference(s)

Waymire KG, Mahuren JD, Jaje JM, Guilarte TR, Coburn SP, MacGregor GR, Mice lacking tissue non-specific alkaline phosphatase die from seizures due to defective metabolism of vitamin B-6. Nat Genet. 1995 Sep;11(1):45-51

Infantile Hypophosphatasia

Phenotype(s)

MGI:2654850

Reference(s)

Narisawa S, Frohlander N, Millan JL, Inactivation of two mouse alkaline phosphatase genes and establishment of a model of infantile hypophosphatasia. Dev Dyn. 1997 Mar;208(3):432-46

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