Nos1-KO

Nomenclature

C57BL/6Smoc-Nos1em1Smoc

Cat. NO.

NM-KO-240406

Strain State

Developing

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Gene Summary

Gene Symbol
Nos1

Synonyms

NO; NOS; bNOS; nNOS; N-NOS; NOS-I; Nos-1; NC-NOS; 2310005C01Rik

NCBI ID

18125

MGI ID

97360

Ensembl ID

ENSMUSG00000029361

Pubmed

Nos1

Human Ortholog

NOS1

Model Description

The exon 1 of Nos1 gene was deleted to generate Nos1 knockout mouse.

Disease Connection

Hypertrophic Cardiomyopathy

Phenotype(s)

MGI:4367213
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Nos3-KO(NM-KO-18022) mice.

Reference(s)

Barouch LA, Cappola TP, Harrison RW, Crone JK, Rodriguez ER, Burnett AL, Hare JM, Combined loss of neuronal and endothelial nitric oxide synthase causes premature mortality and age-related hypertrophic cardiac remodeling in mice. J Mol Cell Cardiol. 2003 Jun;35(6):637-44

Nephrogenic Diabetes Insipidus

Phenotype(s)

MGI:3789190
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Nos2-KO(NM-KO-18027) and Nos3-KO(NM-KO-18022) mice.

Reference(s)

Morishita T, Tsutsui M, Shimokawa H, Sabanai K, Tasaki H, Suda O, Nakata S, Tanimoto A, Wang KY, Ueta Y, Sasaguri Y, Nakashima Y, Yanagihara N, Nephrogenic diabetes insipidus in mice lacking all nitric oxide synthase isoforms. Proc Natl Acad Sci U S A. 2005 Jul 26;102(30):10616-21

Achalasia

Phenotype(s)

MGI:3618910

Reference(s)

Sivarao DV, Mashimo HL, Thatte HS, Goyal RK, Lower esophageal sphincter is achalasic in nNOS(-/-) and hypotensive in W/W(v) mutant mice. Gastroenterology. 2001 Jul;121(1):34-42

Hypertrophic Pyloric Stenosis

Phenotype(s)

MGI:2174975

Reference(s)

Huang PL, Dawson TM, Bredt DS, Snyder SH, Fishman MC, Targeted disruption of the neuronal nitric oxide synthase gene. Cell. 1993 Dec 31;75(7):1273-86

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