Idua-KO

Nomenclature

C57BL/6Smoc-Iduaem/Smoc

Cat. NO.

NM-KO-230255

Strain State

Sperm cryopreservation

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Gene Summary

Gene Symbol
Idua

Synonyms

6030426D08

NCBI ID

15932

MGI ID

96418

Ensembl ID

ENSMUSG00000033540

Pubmed

Idua

Human Ortholog

IDUA

Model Description

The exon 4-13 of Idua gene was deleted to generate Idua knockout mice.

Disease Connection

Mucopolysaccharidosis I

Phenotype(s)

MGI:3587410

Reference(s)

Clarke LA, Russell CS, Pownall S, Warrington CL, Borowski A, Dimmick JE , Toone J , Jirik FR, Murine mucopolysaccharidosis type I: targeted disruption of the murine alpha-L-iduronidase gene. Hum Mol Genet. 1997 Apr;6(4):503-11

Otitis Media

Phenotype(s)

MGI:2651485

Reference(s)

Schachern PA, Cureoglu S, Tsuprun V, Paparella MM, Whitley CB, Age-related functional and histopathological changes of the ear in the MPS I mouse. Int J Pediatr Otorhinolaryngol. 2007 Feb;71(2):197-203

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