hIL1RL1

Nomenclature

C57BL/6Smoc-Il1rl1tm4(hIL1RL1)/Smoc

Cat. NO.

NM-HU-2000067

Strain State

Sperm cryopreservation

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Gene Summary

Gene Symbol
Il1rl1

Model Description

The endogenous mouse Il1rl1 gene was replaced by human IL1RL1 gene.

Research Application:Cytokine humanization model;drug screening

Validation Data

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Fig1. Detection of IL1RL1 expression in large intestine by RT-PCR in hIL1RL1 mice

Wild type: only one band at 296 bp with primers F1/R1(mIl1rl1);

Homoygous: only one band at 367 bp with primers F2/R2(hIL1RL1); 

Abbr. M, DNA marker; HO, homozygous; HE, heterozygous; WT, wild type.

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Fig2. Expression of hIL1RL1 on CD4+ T cells in spleen in hIL1RL1/hIL4/hIL4R mice (NM-HU-232112), which were generated by crossing hIL4/hIL4R (NM-HU-2000106) with hIL1RL1 (NM-HU-2000067).

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Fig3. Expression of hIL1RL1 on mast cells in bone marrow in hIL1RL1/hIL4/hIL4R mice (NM-HU-232112), which were generated by crossing hIL4/hIL4R (NM-HU-2000106) with hIL1RL1 (NM-HU-2000067).


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